Oliver's mTOR Atlas Evidence Platform
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Everything the landmark literature shows me about mTOR — and everything it doesn't

The mTOR Atlas maps a single signalling pathway by what the evidence can actually carry — every claim with its source, the conditions it was measured under, and the point where it stops holding: species, sex, dose, nutrient state, duration.

That boundary layer is the part other resources drop. Alongside it the Atlas keeps what the literature has tested and failed to show, and holds an important distinction throughout: what has been demonstrated, what is an interpretation, and what remains a hypothesis.

526
most relevant studies
50
tested in humans
423
animal + mechanistic
1975
the story begins

Explore the Atlas

Pathway Molecular components and mechanisms connected into a navigable view of the mTOR system. interactive map Studies Explore the underlying evidence, compare findings and follow results back to the original research. 526 studies Researchers The people behind the field, and how different groups shaped our understanding of mTOR. 3723 names · 929 with a profile The Field How the field got here, who trained whom, and what it still does not know. 30 milestones · 180 scientists in the lab tree Academy Learn the biology from the beginning, then practise reading evidence. lessons & arena Events Conferences and meetings — where mTOR research is happening right now. 53 events

The evidence pyramid

526 studies, sorted by how directly each one can speak to an outcome in people — from test-tube mechanisms at the base to human trials at the top. Colours match the evidence markers used throughout the Atlas.

Systematic Reviewmeta-analyses
3
Human Clinical TrialRCTs, phase 2/3
30
Human Observationalnon-randomized
20thin tier
Animal Studymouse, fly, worm…
155
Mechanistic / In Vitrocells, biochemistry, structure
268 10% Direct human evidence 30 clinical trials + 20 observational studies — where we learn what works in patients 80% Animal + mechanistic 155 animal + 268 mechanistic — causal biology, not yet in people
The whole Atlas · 526 records 476 in the pyramid · 50 beside it

Outlined records describe a form of publication, not a level of evidence, so they sit beside the pyramid rather than inside it.

The letter on a record says what kind of study produced a finding — not how good it is. What the evidence codes mean →

Only 10% of that corpus is primary human research (clinical trials and observational studies; the evidence audit also counts 3 systematic reviews of human data). The rest is animal, cellular or theoretical — which is what the pathway can currently carry, not a criticism of it. What the Atlas is actually built on →

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